|
KMID : 1025520120540050323
|
|
Journal of Animal Science and Technology
2012 Volume.54 No. 5 p.323 ~ p.329
|
|
|
Genome Wide Association Study to Identity QTL for Growth Taits in Hanwoo
|
|
Lee Seung-Hwan
Lim Da-Jeong
Jang Gul-Won
Cho Yong-Min
Choi Bong-Hwan
Kim Si-Dong
Oh Sung-Jong
Lee Jun-Heon
Yoon Du-Hak
Park Eung-Woo
Lee Hak-Kyo
Hong Seong-Koo
Yang Boh-Suck
|
|
|
Abstract
|
|
|
|
Genome-wide association study was performed on data from 266 Hanwoo steers derived from 66 sires using bovine 10K mapping chip in Hanwoo (Korean cattle). SNPs were excluded from the analysis if they failed in over 5% of the genotypes, had median GC scores below 0.6, had GC scores under 0.6 in less than 90% of the samples, deviated in heterozygosity more than 3standard deviations from the other SNPs and were out of Hardy-Weinberg equilibrium for a cut-off p-value of 1－15. Unmapped and SNPs on sex chromosomes were also excluded. A total of 4,522 SNPs were included in the analysis. To test an association between SNP and QTL, a single marker regression analysis was implemented in this study. SNP was assumed to be in LD with QTL in close proximity and the effect evaluated was additive effect (QTL allele substitution effect). The number of significant SNP at a threshold of P<0.001 was 3, 5, 5 and 4 loci for live weight at 6, 12, 18 and 24 months, respectively. For live weight at different ages, significant SNP were spread out across chromosome but some of significant SNP (rs29012453 and rs29012456on BTA24) had shown highly significant effects. As for the distribution of size of SNP effects, few loci for live weight at different age had moderate effects (6~11%) but most of significant loci had small effects (2 to 5% of additive genetic variance)against total additive genetic variance. In conclusion, live weight at different age might be affected by few loci with moderate effect and many loci with small effects across genome in Hanwoo.
|
|
|
KEYWORD
|
|
|
Genome wide association study, Growth traits and Hanwoo
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|